ABSTRACT
Objective To investigate the effects and mechanism of rosiglitazone on carotid intima-media thickness(IMT)in patients with type 2 diabetes mellitus(DM)by carotid ultrssonography.Methods Fifty-nine patienta with obese DM were divided into two groups randomly:patients in control group(n=29)received routine therapy.and patients in treatment group(n=30)received rosiglitzone with routine therapy for 24 months.Carotid IMT was measured by carotid ultrasonography pre-and post-therapy.The level of ma-trix metalloproteinase-9(MMPO)and C-reactive protein(CRP)were assayed.Results Compared with control group,the IMT was decreased following irosiglitazone therapy(P＜0.05).The concentrations of MMP-9 and CRP in patients in the treatment group were (253.4±97.5)ng/L and(1.15±0.96)mg/L,and those in the control group were(361.8±101.7)ng/L and (2.18±2.01)mg/L,which were significantly impmved.Conclusion Rosiglitazone could retard atherosclerosis progression in obese patients with type 2 DM which was achieved through improving MMP-9 and CRP.
ABSTRACT
Objective To investigate the effect of chemotherapy drugs on the expression of carci-noembryonic antigen (CEA) in the gastric tissue with precancerous lesions in ectopie cancer. Methods There were 45 cases of cancer patients (precancerous lesions group), the pathological biopsy showed that there were atypical hyperplasia or intestinal metaplasia by gastroscope before chemotherapy. Gastruscope was done before chemotherapy and after six cycles of chemotherapy. Gastric tissue was taken respectively in the same site. The expression of CEA was measured in the gastric tissue. Normal gastric tissue taken from 10 cases of cancer patients was served as control. Compared respectively the expression of CEA in the gastric tissue in control group and precancerous lesions group, in precancerous lesions group between before and after treatment. Results CEA expression in the gastric tissue was (27.76±9.67), (3.32±0.60)μg/L in precancerous lesions group and control group respectively, there was significant difference between two groups(P<0.05). CEA expression in the gastric tissue was (27.76±9.67), (26.60±10.80)μg/L before and after treatment in precancerous lesions group respectively, P<0.05. CEA expression in the gastric tissue before treatment was (23.11±4.11), (17.10±1.66)μg/L, after treatment was (21.11±5.66), (15.10±3.31)μg/L in the mild to moderate atypical hyperplasia, mild to moderate intestinal metaplasia respectively, there was significant difference between before and after treatment in the mild to moderate precancerous lesions. There was no significant difference between before and after treatment in the severe precancerous lesions. Conclusions Chemotherapy drugs can significantly reduce the expression of CEA in the gastric tis-sue in the mild to moderate precancerous lesions. The results suggests that mild to moderate precancerous lesions can be reversed.